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Demir Kadın Neslican tells the life story of "Iron Woman" Neslican Tay, who gave hope to people with her struggle to cling to life while undergoing cancer treatment. The film recounts the difficult treatment process that began when she was diagnosed with cancer, revealing Neslican's experiences during this period and her struggle to cling to life.

Arif is a retired family man who has fallen in love with acting. While working as an extra on TV series sets in the hope of being discovered, he is accidentally cast in a two-page role as a doctor. This role will also cause him to experience the most traumatic day of his life.

Fiko and Kamil are two friends struggling to make ends meet. They mortgaged their families' homes and borrowed money from the bank and loan shark Rıfat to open a snack bar in their neighborhood. When Rıfat suddenly decides to take both their homes and their shop by moving up the payment date on the promissory note he holds, the duo finds themselves in a bind and strikes a deal with Cafer, the neighborhood's sharp-witted student, to get their business back on track and make money. Seeing that the duo is making money, Rıfat sets their shop on fire, putting them in an even more difficult situation. While Fiko and Kamil try to settle their debts with Rıfat, they find themselves caught in the middle of a war between Rıfat and another mafia boss, Süleyman. The duo will try to escape this struggle and save themselves, caught between Fiko's angelic-looking but immoral teenage brother Taki, their families, and Kamil's long-time love interest Gülay.