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A UFC Middleweight Championship rematch between current champion Alex Pereira (also former Glory Middleweight and Light Heavyweight Champion) and former champion Israel Adesanya is expected to headline the event. The pairing previously met at UFC 281 in which Pereira captured the title by fifth round knockout. The two also previously met twice in kickboxing matchups. The first in April 2016 which Pereira won by unanimous decision. Their second meeting took place at Glory of Heroes 7 in March 2017 which Pereira won by third round knockout.

UFC on ESPN 41: Vera vs. Cruz was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on August 13, 2022, at Pechanga Arena in San Diego, California, United States. A bantamweight bout between Marlon Vera and former two-time UFC Bantamweight Champion (also former WEC Bantamweight Champion) Dominick Cruz headlined the event.

UFC 266: Volkanovski vs. Ortega was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on September 25, 2021 at the T-Mobile Arena in Paradise, Nevada, part of the Las Vegas Metropolitan Area, United States. A UFC Featherweight Championship bout between current champion Alexander Volkanovski and former title challenger Brian Ortega headlined the event.

145 lbs.: Max Holloway vs. Yair Rodriguez 265 lbs.: Marcos Rogerio de Lima vs. Ben Rothwell 145 lbs.: Leah Letson vs. Felicia Spencer 205 lbs.: Philipe Lins vs. Ovince Saint Preux

UFC on ESPN 10: Eye vs. Calvillo was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on June 13, 2020 at the UFC Apex facility in Enterprise, Nevada, part of the Las Vegas Metropolitan Area, United States. The women's flyweight bout between former UFC Women's Flyweight Championship challenger Jessica Eye and Cynthia Calvillo served as the new event headliner.

UFC 255: Figueiredo vs. Perez was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on November 21, 2020 at the UFC Apex facility in Enterprise, Nevada, part of the Las Vegas Metropolitan Area, United States. A UFC Flyweight Championship bout between current champion Deiveson Figueiredo and former UFC Bantamweight Champion Cody Garbrandt was expected to serve as the event headliner. However, it was announced on October 2 that Garbrandt pulled out due to a torn bicep and was replaced by Alex Perez, who was already scheduled to face Brandon Moreno at the event.

UFC on ESPN 1: Ngannou vs. Velasquez was a mixed martial arts event produced by the Ultimate Fighting Championship that was held on February 17, 2019 at Talking Stick Resort Arena, now known as Footprint Center in Phoenix, Arizona, United States. A heavyweight bout between former two-time UFC Heavyweight Champion Cain Velasquez and former title challenger Francis Ngannou served as the event headliner.

UFC on ESPN 7: Overeem vs. Rozenstruik was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on December 7, 2019 at Capital One Arena in Washington, D.C., United States. A heavyweight bout between former 2010 K-1 World Grand Prix Champion, Strikeforce Heavyweight Champion and UFC Heavyweight Championship challenger Alistair Overeem and Jairzinho Rozenstruik served as the headliner.

UFC Fight Night 140: Magny vs. Ponzinibbio was a mixed martial arts event produced by the Ultimate Fighting Championship that was held on November 17, 2018 at Estadio Mary Terán de Weiss in Buenos Aires, Argentina. A welterweight bout between Neil Magny and Santiago Ponzinibbio headlined the event.

UFC Fight Night 113: Nelson vs. Ponzinibbio was a mixed martial arts event produced by the Ultimate Fighting Championship held on July 16, 2017 at The SSE Hydro in Glasgow, Scotland. A welterweight bout between Gunnar Nelson and Santiago Ponzinibbio headlined the event.
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