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ER doctor Tsuyoshi Matsuoka receives a patient with a virus unlike anything he's seen before. His symptoms include high fever, convulsions, vomiting of blood and multiple organ failure. Could this be a new form of influenza or is it some other variety of virus? As the situation worsens and more cases begin arriving, a medical officer from the World Health Organization named Eiko Kobayashi is dispatched to the area. At the rate the virus is spreading, the entire city’s transportation system and infrastructure would be brought to a halt within 3 months. Within 6 months it could spread to tens of millions of people--reaching a death toll far worse than any war.

The story of a teenage boy named Yu, who falls for Yoko, a girl he runs into while operating for the sake of sin as an "up-skirt" photographer. His attempts to woo her are complicated by a spot of cross-dressing – which convinces Yoko that she is lesbian – dalliances with kung-fu and crime, and a constant struggle with the guilt that's a legacy of his Catholic upbringing.

The movie's title is a play on the popular Always - Sunset on Third Street films and also deals with circumstances 1950's Tokyo, but focuses on the homosexual district of Shinjuku ni-chome.
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