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A massive volcanic eruption has occurred on a remote island in the southern seas, creating an unprecedented disaster. The Nankai MER members must go save everyone in the island.

A novice red blood cell and a relentless white blood cell work together to protect their human from invading germs, pathogens and other threats.

Half a year has passed since the official approval of TOKYO MER. Kitami is racking his brains over the issue of a second doctor to replace Otowa, who has left the team in order to expand MER to ordinance-designated cities nationwide. Some members of the team want Hina to be promoted, but Otowa asserts that Hina should pursue her path of cardiovascular surgery. She felt the pressure that Hina could take Otowa's place, and she was troubled.

The individuals that comprise the Tokyo MER team rush to on-site disasters and accidents, performing life-saving treatment thanks to the OR equipped within their vehicle. Their one mission is simple: leave no one dead. But conflicts arise when an unprecedented event rocks Yokohama after a bomb explodes in Landmark Tower, leaving thousands fighting to escape. Although the chief doctor Kitami believes they should not wait and presses for a quick dispatch, the more level-headed Chief Kamoi of the elite Yokohama MER thinks otherwise — they need to wait until the area is safe to enter, or they won’t be able to save anyone.

Yoko, who gets a job at a nursing home, witnesses the elderly and disabled people there having their human dignity threatened.

26 years old Hanako is on the verge of directing her first-ever feature film, achieving her childhood dream. Although she’s being hindered by an older male assistant director, she has a fateful encounter with a man named Masao, and her life at last begins to take on a whole new luster. However, the underhanded actions of an unscrupulous producer cause Hanako to have her personal project stolen. After being dumped into despair, she quietly stokes her rage, and makes a pledge to keep fighting, and never back down! Entangling Masao, her hopeless father and two older brothers (who she’s been out of touch with for over 10 years) in her obsessive quest, Hanako audaciously attempts to make her dream come true, her way!

Sakota Yui is a senior high school student living in a seaside town. Her parents own a beauty salon and she dreams of going to the big city for college to learn art. One day, Yui sees her father heading to a funeral home. She follows him and finds out that her father is working a job where he listens to the bereaved family and sets the deceased's hair before the coffin is laid to rest, which is called "Ending Cut".

Anzai, Mutoh, Hamada, Hagiwara, and Miru are in a car headed to a love hotel used by the Sugiyama Clan for money laundering. This one night only gang succeed in robbing them blind and though they were supposed to go their separate ways after splitting the money, the five end up being hunt down by a detective hired by the clan and clan members themselves. An ending nobody ever even dreamed of.

Madarame Baku is a mysterious gambler. His nickname is Usogui (literally The Lie Eater). Club Kakerou is the top illegal gambling den, where gamblers vie to become the best in their profession. Seeing through the lies of others, Madarame Baku challenges a variety of high stakes games at Club Kakerou.

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