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Agent Jack Ryan becomes acting Deputy Director of Intelligence for the CIA when Admiral Greer is diagnosed with cancer. When an American businessman, and friend of the president, is murdered on his yacht, Ryan starts discovering links between the man and drug dealers. As former CIA agent John Clark is sent to Colombia to kill drug cartel kingpins in retaliation, Ryan must fight through multiple cover-ups to figure out what happened and who's responsible.

Tired of being treated like a child by everyone due to his physical limitations, Jonathan, 29, embarks on a wild and heartfelt trip to Panama with unlikely companions to confront the doctor who caused his disability.