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Robyn McCall, an enigmatic former CIA operative with a mysterious background, uses her extensive skills to help those with nowhere else to turn.

The new medical director breaks the rules to heal the system at America's oldest public hospital. Max Goodwin sets out to tear up the bureaucracy and provide exceptional care, but the doctors and staff are not so sure he can succeed. They've heard this before. Not taking "no" for an answer, Dr. Goodwin's instinctive response to problems large and small is four simple words: "How can I help?" He has to disrupt the status quo and prove he'll stop at nothing to breathe new life into this underfunded and underappreciated hospital, returning it to the glory that put it on the map.

20-something Angus MacGyver creates a clandestine organization where he uses his knack for solving problems in unconventional ways to help prevent disasters from happening.

Dr. Temperance Brennan and her colleagues at the Jeffersonian's Medico-Legal Lab assist Special Agent Seeley Booth with murder investigations when the remains are so badly decomposed, burned or destroyed that the standard identification methods are useless.

Ryan Atwood, a teen from the wrong side of the tracks, moves in with a wealthy family willing to give him a chance. But Ryan's arrival disturbs the status quo of the affluent, privileged community of Newport Beach, California.

A sportscaster becomes a full-time dad when his ex-wife decides to accept a job out of the country and his teenage daughter, Breanna, moves in with him.

The vampire Angel, cursed with a soul, moves to Los Angeles and aids people with supernatural-related problems while questing for his own redemption. A spin-off from Buffy the Vampire Slayer.
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